Tried using Estrogen - there's a mistake

I'd heard somewhere that B6 absorption may be reduced by the estrogen in foods.  I'd also read some personal accounts where the neuropathy symptoms were impacted, depending on where the woman was in her cycle.  In fact, while on my period last month, my symptoms dramatically improved.

• Question:  Will using estriol improve my symptoms or have any impact?  
• Experiment:  On day #10 of my cycle, I tried some micronized natural estriol on my arm.
• Results:  Neuropathy symptoms *very* noticeably worsened.  Tingling/burning on my hands and feet dramatically increased.  Also interesting was that there was a lot of tingling on the arm itself, where I'd put on the cream.

Bottom Line:  I'm not going to be doing this again any time soon!  Interesting though that estrogen did seem to have an affect, albeit not the one to which I'd hoped.
    
General Notes:  I'd used the estriol before any toxicity problems - so I trust the brand and my usual reactions to it.  I put it on before going to bed.  To measure days of the cycle - 1st day of period = day #1 of the cycle.  I'm in my late 40s, but still have regular cycles.